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Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction.

ABSTRACT: Ammonia in the tetrazole Ugi variation together with ?-amino acid methyl ester-derived isocyanides provides tetrazolopiperidinones in good to high yields in one pot. The scope and limitations of this reaction were investigated by performing >70 reactions. The scaffold is useful to fill high-throughput screening decks and in structure-based drug design.

SUBMITTER: Patil P

PROVIDER: S-EPMC5424440 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Ammonia-Promoted One-Pot Tetrazolopiperidinone Synthesis by Ugi Reaction.

Patil Pravin P Kurpiewska Katarzyna K Kalinowska-Tłuścik Justyna J Dömling Alexander A

ACS combinatorial science 20170308 5

Ammonia in the tetrazole Ugi variation together with α-amino acid methyl ester-derived isocyanides provides tetrazolopiperidinones in good to high yields in one pot. The scope and limitations of this reaction were investigated by performing >70 reactions. The scaffold is useful to fill high-throughput screening decks and in structure-based drug design. ...[more]

PMID: 28240545

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