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Asymmetric synthesis of CF₂-functionalized aziridines by combined strong Bronsted acid catalysis.

ABSTRACT: A diastereo- and enantioselective approach to access chiral CF₂-functionalized aziridines from difluorodiazoethyl phenyl sulfone (PhSO₂CF₂CHN₂) and in situ-formed aldimines is described. This multicomponent reaction is enabled by a combined strong Brønsted acid catalytic platform consisting of a chiral disulfonimide and 2-carboxyphenylboronic acid. The optical purity of the obtained CF₂-substituted aziridines could be further improved by a practical dissolution-filtration procedure.

SUBMITTER: Tan XF

PROVIDER: S-EPMC7155912 | biostudies-literature |

REPOSITORIES: biostudies-literature

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