Ontology highlight
ABSTRACT:
SUBMITTER: Kovaleva IE
PROVIDER: S-EPMC7156099 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Kovaleva Irina E IE Tokarchuk Artem V AV Zheltukhin Andrei O AO Dalina Alexandra A AA Safronov Grigoriy G GG Evstafieva Alexandra G AG Lyamzaev Konstantin G KG Chumakov Peter M PM Budanov Andrei V AV Budanov Andrei V AV
PloS one 20200414 4
SESN2 is a member of the evolutionarily conserved sestrin protein family found in most of the Metazoa species. The SESN2 gene is transcriptionally activated by many stress factors, including metabolic derangements, reactive oxygen species (ROS), and DNA-damage. As a result, SESN2 controls ROS accumulation, metabolism, and cell viability. The best-known function of SESN2 is the inhibition of the mechanistic target of rapamycin complex 1 kinase (mTORC1) that plays a central role in support of cell ...[more]