Ontology highlight
ABSTRACT:
SUBMITTER: Al-Khalaf HH
PROVIDER: S-EPMC7156216 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Al-Khalaf Huda H HH Ghebeh Hazem H Wakil Salma M SM Al-Mohanna Falah F Aboussekhra Abdelilah A
Molecular and cellular biology 20200413 9
During aging, cellular plasticity and senescence play important roles in tissue regeneration and the pathogenesis of different diseases, including cancer. We have recently shown that senescent breast luminal cells can activate their adjacent stromal fibroblasts. In the present report, we present clear evidence that these senescence-related active fibroblasts can dedifferentiate proliferating primary human luminal cells to multipotent stem cells in an interleukin-8 (IL-8)-dependent manner. This w ...[more]