Enhanced myostatin expression and signalling promote tubulointerstitial inflammation in diabetic nephropathy.
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SUBMITTER: Verzola D
PROVIDER: S-EPMC7156449 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
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Enhanced myostatin expression and signalling promote tubulointerstitial inflammation in diabetic nephropathy.
Verzola Daniela D Milanesi Samantha S Viazzi Francesca F Ansaldo Francesca F Saio Michela M Garibaldi Silvano S Carta Annalisa A Costigliolo Francesca F Salvidio Gennaro G Barisione Chiara C Esposito Pasquale P Garibotto Giacomo G Picciotto Daniela D
Scientific reports 20200414 1
Myostatin (MSTN), a family member of the transforming growth factor (TGF)-β super family, has been detected in the tubuli of pig kidney, but its role in the human kidney is not known. In this study we observed upregulation of MSTN mRNA (~8 to 10-fold increase) both in the glomeruli and tubulointerstitium in diabetic nephropathy (DN). In DN, immunoreactive MSTN was mainly localized in the tubuli and interstitium (∼4-8 fold increase), where it colocalized in CD45<sup>+</sup> cells. MSTN was also u ...[more]
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