Ontology highlight
ABSTRACT:
SUBMITTER: Daniels J
PROVIDER: S-EPMC7156460 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Daniels Jay J Doukas Peter G PG Escala Maria E Martinez MEM Ringbloom Kimberly G KG Shih David J H DJH Yang Jingyi J Tegtmeyer Kyle K Park Joonhee J Thomas Jane J JJ Selli Mehmet E ME Altunbulakli Can C Gowthaman Ragul R Mo Samuel H SH Jothishankar Balaji B Pease David R DR Pro Barbara B Abdulla Farah R FR Shea Christopher C Sahni Nidhi N Gru Alejandro A AA Pierce Brian G BG Louissaint Abner A Guitart Joan J Choi Jaehyuk J
Nature communications 20200414 1
Primary cutaneous γδ T cell lymphomas (PCGDTLs) represent a heterogeneous group of uncommon but aggressive cancers. Herein, we perform genome-wide DNA, RNA, and T cell receptor (TCR) sequencing on 29 cutaneous γδ lymphomas. We find that PCGDTLs are not uniformly derived from Vδ2 cells. Instead, the cell-of-origin depends on the tissue compartment from which the lymphomas are derived. Lymphomas arising from the outer layer of skin are derived from Vδ1 cells, the predominant γδ cell in the epiderm ...[more]