Ontology highlight
ABSTRACT:
SUBMITTER: Maslov DA
PROVIDER: S-EPMC7157563 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Maslov Dmitry A DA Shur Kirill V KV Vatlin Aleksey A AA Danilenko Valery N VN
Pathogens (Basel, Switzerland) 20200228 3
The emergence and spread of drug-resistant <i>Mycobacterium tuberculosis</i> strains (including MDR, XDR, and TDR) force scientists worldwide to search for new anti-tuberculosis drugs. We have previously reported a number of imidazo[1,2-<i>b</i>][1,2,4,5]tetrazines - putative inhibitors of mycobacterial eukaryotic-type serine-threonine protein-kinases, active against <i>M. tuberculosis</i>. Whole genomic sequences of spontaneous drug-resistant <i>M. smegmatis</i> mutants revealed four genes poss ...[more]