Compression of dynamic tactile information in the human hand.
Ontology highlight
ABSTRACT:
SUBMITTER: Shao Y
PROVIDER: S-EPMC7159916 | biostudies-literature |
REPOSITORIES: biostudies-literature
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Project description:Sense of body ownership is an immediate and distinct experience of one's body as belonging to oneself. While it is well-recognized that ownership feelings emerge from the integration of visual and somatosensory signals, the principles upon which they are integrated are still intensely debated. Here, we used the rubber hand illusion (RHI) to examine how the interplay of visual, tactile, and proprioceptive signals is governed depending on their spatiotemporal properties. For this purpose, the RHI was elicited in different conditions varying with respect to the extent of visuo-proprioceptive divergence (i.e., the distance between the real and fake hands) and differing in terms of the availability and spatiotemporal complexity of tactile stimulation (none, simple, or complex). We expected that the attenuating effect of distance on illusion strength will be more pronounced in the absence of touch (when proprioception gains relatively higher importance) and absent in the presence of complex tactile signals. Additionally, we hypothesized that participants with greater proprioceptive acuity-assessed using an elbow joint position discrimination task-will be less susceptible to the illusion, but only under the conditions of limited tactile stimulation. In line with our prediction, RHI was attenuated at the farthest distance only when tactile information was absent or simplified, but the attenuation was effectively prevented by the use of complex tactile stimulation-in this case, RHI was comparably vivid at both distances. However, passive proprioceptive acuity was not related to RHI strength in either of the conditions. The results indicate that complex-structured tactile signals can override the influence of proprioceptive signals in body attribution processes. These findings extend our understanding of body ownership by showing that it is primarily determined by informative cues from the most relevant sensory domains, rather than mere accumulation of multisensory evidence.
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Project description:BackgroundLower limb somatosensation and proprioception are important for maintaining balance. Research has shown that compression garments or exposure to textured surfaces, can enhance somatosensation however, little is known about the effect of combined compression and texture on somatosensory acuity in the lower limb. This study aimed to assess the effects of combined compression socks with a plantar textured sole, on lower limb somatosensory acuity.MethodsThirty participants completed a somatosensory acuity task (active movement extent discrimination apparatus; AMEDA) under three conditions: barefoot (control condition), standard knee-high compression sock (compression sock), and knee-high compression sock with internal rubber nodules situated on the sole (textured-compression sock). Somatosensory acuity was assessed between the different sock conditions for the (i) entire group, (ii) high performers, and (iii) low performers. It was hypothesized that low performers would see gains wearing either sock, but the greatest improvement would be in the textured-compression sock condition.ResultsAMEDA scores were not significantly different between conditions when the entire group was analyzed (p = 0.078). The low performers showed an improvement in somatosensory acuity when wearing the compression sock (p = 0.037) and the textured compression sock (p = 0.024), when compared to barefoot, but there was no difference between the two sock conditions (p > 0.05). The high performers did not show any improvement (p > 0.05 for all).ConclusionThese findings demonstrate that additional sensory feedback may be beneficial to individuals with lower baseline somatosensory acuity but is unlikely to provide benefit for those with higher somatosensory acuity.
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Project description:As a surrogate for human tactile cognition, an artificial tactile perception and cognition system are proposed to produce smooth/soft and rough tactile sensations by its user's tactile feeling; and named this system as "tactile avatar". A piezoelectric tactile sensor is developed to record dynamically various physical information such as pressure, temperature, hardness, sliding velocity, and surface topography. For artificial tactile cognition, the tactile feeling of humans to various tactile materials ranging from smooth/soft to rough are assessed and found variation among participants. Because tactile responses vary among humans, a deep learning structure is designed to allow personalization through training based on individualized histograms of human tactile cognition and recording physical tactile information. The decision error in each avatar system is less than 2% when 42 materials are used to measure the tactile data with 100 trials for each material under 1.2N of contact force with 4cm s-1 of sliding velocity. As a tactile avatar, the machine categorizes newly experienced materials based on the tactile knowledge obtained from training data. The tactile sensation showed a high correlation with the specific user's tendency. This approach can be applied to electronic devices with tactile emotional exchange capabilities, as well as advanced digital experiences.
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Project description:When we grasp and manipulate an object, populations of tactile nerve fibers become activated and convey information about the shape, size, and texture of the object and its motion across the skin. The response properties of tactile fibers have been extensively characterized in single-unit recordings, yielding important insights into how individual fibers encode tactile information. A recurring finding in this extensive body of work is that stimulus information is distributed over many fibers. However, our understanding of population-level representations remains primitive. To fill this gap, we have developed a model to simulate the responses of all tactile fibers innervating the glabrous skin of the hand to any spatiotemporal stimulus applied to the skin. The model first reconstructs the stresses experienced by mechanoreceptors when the skin is deformed and then simulates the spiking response that would be produced in the nerve fiber innervating that receptor. By simulating skin deformations across the palmar surface of the hand and tiling it with receptors at their known densities, we reconstruct the responses of entire populations of nerve fibers. We show that the simulated responses closely match their measured counterparts, down to the precise timing of the evoked spikes, across a wide variety of experimental conditions sampled from the literature. We then conduct three virtual experiments to illustrate how the simulation can provide powerful insights into population coding in touch. Finally, we discuss how the model provides a means to establish naturalistic artificial touch in bionic hands.
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Project description:This study investigates the transcriptome response of meniscus fibrochondrocytes (MFCs) to the low oxygen and mechanical loading signals experienced in the knee joint using a model system. We hypothesized that short term exposure to the combined treatment would promote a matrix-forming phenotype supportive of inner meniscus tissue formation. Human MFCs on a collagen scaffold were stimulated to form fibrocartilage over 6weeks under normoxic (NRX, 20% O2) conditions with supplemented TGF -β3. Tissues experienced a delayed 24h hypoxia treatment (HYP, 3% O2) and then 5min of dynamic compression (DC) between 30 and 40% strain. Delayed HYP induced an anabolic and anti-catabolic expression profile for hyaline cartilage matrix markers, while DC induced an inflammatory matrix remodeling response along with upregulation of both SOX9 and COL1A1. There were 41 genes regulated by both HYP and DC. Overall, the combined treatment supported a unique gene expression profile favouring the hyaline cartilage aspect of inner meniscus matrix and matrix remodeling.
2021-02-17 | GSE166908 | GEO
Project description:Locating a tactile stimulus on the body seems effortless and straightforward. However, the perceived location of a tactile stimulation can differ from its physical location [1-3]. Tactile mislocalizations can depend on the timing of successive stimulations [2, 4, 5], tactile motion mechanisms [6], or processes that "remap" stimuli from skin locations to external space coordinates [7-11]. We report six experiments demonstrating that the perception of tactile localization on a static body part is strongly affected by the displacement between the locations of two successive task-irrelevant actions. Participants moved their index finger between two keys. Each keypress triggered synchronous tactile stimulation at a randomized location on the immobilized wrist or forehead. Participants reported the location of the second tactile stimulation relative to the first. The direction of either active finger movements or passive finger displacements biased participants' tactile orientation judgements (experiment 1). The effect generalized to tactile stimuli delivered to other body sites (experiment 2). Two successive keypresses, by different fingers at distinct locations, reproduced the effect (experiment 3). The effect remained even when the hand that moved was placed far from the tactile stimulation site (experiments 4 and 5). Temporal synchrony within 600 ms between the movement and tactile stimulations was necessary for the effect (experiment 6). Our results indicate that a dynamic displacement vector, defined as the location of one sensorimotor event relative to the one before, plays a strong role in structuring tactile spatial perception.
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Project description:This study investigates the transcriptome response of meniscus fibrochondrocytes (MFCs) to the low oxygen and mechanical loading signals experienced in the knee joint using a model system. We hypothesized that short term exposure to the combined treatment would promote a matrix-forming phenotype supportive of inner meniscus tissue formation. Human MFCs on a collagen scaffold were stimulated to form fibrocartilage over 6 weeks under normoxic (NRX, 20% O2) conditions with supplemented TGF-β3. Tissues experienced a delayed 24h hypoxia treatment (HYP, 3% O2) and then 5 min of dynamic compression (DC) between 30 and 40% strain. Delayed HYP induced an anabolic and anti-catabolic expression profile for hyaline cartilage matrix markers, while DC induced an inflammatory matrix remodeling response along with upregulation of both SOX9 and COL1A1. There were 41 genes regulated by both HYP and DC. Overall, the combined treatment supported a unique gene expression profile favouring the hyaline cartilage aspect of inner meniscus matrix and matrix remodeling.
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