Ontology highlight
ABSTRACT:
SUBMITTER: Thejer BM
PROVIDER: S-EPMC7160964 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Thejer Bashar M BM Adhikary Partho P PP Teakel Sarah L SL Fang Johnny J Weston Paul A PA Gurusinghe Saliya S Anwer Ayad G AG Gosnell Martin M Jazayeri Jalal A JA Ludescher Marina M Gray Lesley-Ann LA Pawlak Michael M Wallace Robyn H RH Pant Sameer D SD Wong Marie M Fischer Tamas T New Elizabeth J EJ Fehm Tanja N TN Neubauer Hans H Goldys Ewa M EM Quinn Jane C JC Weston Leslie A LA Cahill Michael A MA
BMC molecular and cell biology 20200415 1
<h4>Background</h4>Progesterone receptor membrane component 1 (PGRMC1) is often elevated in cancers, and exists in alternative states of phosphorylation. A motif centered on PGRMC1 Y180 was evolutionarily acquired concurrently with the embryological gastrulation organizer that orchestrates vertebrate tissue differentiation.<h4>Results</h4>Here, we show that mutagenic manipulation of PGRMC1 phosphorylation alters cell metabolism, genomic stability, and CpG methylation. Each of several mutants eli ...[more]