Dataset Information

Mortality prediction to hospitalized patients with influenza pneumonia: PO₂ /FiO₂ combined lymphocyte count is the answer.

ABSTRACT:

Introduction

Community-acquired pneumonia (CAP) severity scores perform well in predicting mortality of CAP patients, but their applicability in influenza pneumonia is powerless.

Objectives

The aim of our research was to test the efficiency of PO₂ /FiO₂ and CAP severity scores in predicting mortality and intensive care unit (ICU) admission with influenza pneumonia patients.

Methods

We reviewed all patients with positive influenza virus RNA detection in Beijing Chao-Yang Hospital during the 2009-2014 influenza seasons. Outpatients, inpatients with no pneumonia and incomplete data were excluded. We used receiver operating characteristic curves (ROCs) to verify the accuracy of severity scores or indices as mortality predictors in the study patients.

Results

Among 170 hospitalized patients with influenza pneumonia, 30 (17.6%) died. Among those who were classified as low-risk (predicted mortality 0.1%-2.1%) by pneumonia severity index (PSI) or confusion, urea, respiratory rate, blood pressure, age ?65 year (CURB-65), the actual mortality ranged from 5.9 to 22.1%. Multivariate logistic regression indicated that hypoxia (PO₂ /FiO₂ ???250) and lymphopenia (peripheral blood lymphocyte count <0.8 × 10⁹ /L) were independent risk factors for mortality, with OR value of 22.483 (95% confidence interval 4.927-102.598) and 5.853 (95% confidence interval 1.887-18.152), respectively. PO₂ /FiO₂ combined lymphocyte count performed well for mortality prediction with area under the curve (AUC) of 0.945, which was significantly better than current CAP severity scores of PSI, CURB-65 and confusion, respiratory rate, blood pressure, age ?65 years for mortality prediction (P?2 /FiO₂ combined lymphocyte count was also the best predictor for predicting ICU admission.

Conclusion

In conclusion, we found that PO₂ /FiO₂ combined lymphocyte count is simple and reliable predictor of hospitalized patients with influenza pneumonia in predicting mortality and ICU admission. When PO₂ /FiO₂ ???250 or peripheral blood lymphocyte count <0.8 × 10⁹ /L, the clinician should pay great attention to the possibility of severe influenza pneumonia.

SUBMITTER: Shi SJ

PROVIDER: S-EPMC7162301 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Publications

Mortality prediction to hospitalized patients with influenza pneumonia: PO<sub>2</sub> /FiO<sub>2</sub> combined lymphocyte count is the answer.

Shi Shu Jing SJ Li Hui H Liu Meng M Liu Ying Mei YM Zhou Fei F Liu Bo B Qu Jiu Xin JX Cao Bin B

The clinical respiratory journal 20150811 3

<h4>Introduction</h4>Community-acquired pneumonia (CAP) severity scores perform well in predicting mortality of CAP patients, but their applicability in influenza pneumonia is powerless.<h4>Objectives</h4>The aim of our research was to test the efficiency of PO<sub>2</sub> /FiO<sub>2</sub> and CAP severity scores in predicting mortality and intensive care unit (ICU) admission with influenza pneumonia patients.<h4>Methods</h4>We reviewed all patients with positive influenza virus RNA detection in ...[more]

PMID: 26148709

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Dataset Information

Mortality prediction to hospitalized patients with influenza pneumonia: PO₂ /FiO₂ combined lymphocyte count is the answer.

Introduction

Objectives

Methods

Results

Conclusion

Publications

Mortality prediction to hospitalized patients with influenza pneumonia: PO<sub>2</sub> /FiO<sub>2</sub> combined lymphocyte count is the answer.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

Mortality prediction to hospitalized patients with influenza pneumonia: PO2 /FiO2 combined lymphocyte count is the answer.

Introduction

Objectives

Methods

Results

Conclusion

Publications

Mortality prediction to hospitalized patients with influenza pneumonia: PO<sub>2</sub> /FiO<sub>2</sub> combined lymphocyte count is the answer.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Mortality prediction to hospitalized patients with influenza pneumonia: PO₂ /FiO₂ combined lymphocyte count is the answer.