Dataset Information

Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc-MKRN2-42:1 in the pathogenesis of Parkinson's disease.

ABSTRACT:

Background

Parkinson's disease (PD) is a common movement disorder for which diagnosis mainly depends on the medical history and clinical symptoms. Exosomes are now considered an additional mechanism for intercellular communication, allowing cells to exchange proteins, lipids, and genetic material. Long noncoding (lnc) RNA in exosomes plays a critical role in many diseases, including neurodegenerative disease.

Aim

To study expression differences for lncRNAs in peripheral blood exosomes of PD patients compared with healthy individuals and to look for lncRNAs that might be related to the pathogenesis of PD.

Materials and methods

We recruited PD patients along with age- and sex-matched healthy individuals as healthy controls and evaluated levels of lncRNAs extracted from exosomes in plasma samples via next-generation sequencing and real-time quantitative PCR. Correlation analysis was conducted for the clinical characteristics of PD patients and the expression of selected lncRNAs.

Results

We found 15 upregulated and 24 downregulated exosomal lncRNAs in the PD group. According to bioinformatics analyses, we chose lnc-MKRN2-42:1 for further study. Interestingly, lnc-MKRN2-42:1 was positively correlated with the MDS-UPDRS III score for PD patients.

Conclusion

Our study suggested that lnc-MKRN2-42:1 may be involved in the occurrence and development of PD.

SUBMITTER: Wang Q

PROVIDER: S-EPMC7163584 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Publications

Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc-MKRN2-42:1 in the pathogenesis of Parkinson's disease.

Wang Qiao Q Han Chun-Lei CL Wang Kai-Liang KL Sui Yun-Peng YP Li Zhi-Bao ZB Chen Ning N Fan Shi-Ying SY Shimabukuro Michitomo M Wang Feng F Meng Fan-Gang FG Meng Fan-Gang FG

CNS neuroscience & therapeutics 20191208 5

<h4>Background</h4>Parkinson's disease (PD) is a common movement disorder for which diagnosis mainly depends on the medical history and clinical symptoms. Exosomes are now considered an additional mechanism for intercellular communication, allowing cells to exchange proteins, lipids, and genetic material. Long noncoding (lnc) RNA in exosomes plays a critical role in many diseases, including neurodegenerative disease.<h4>Aim</h4>To study expression differences for lncRNAs in peripheral blood exos ...[more]

PMID: 31814304

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Dataset Information

Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc-MKRN2-42:1 in the pathogenesis of Parkinson's disease.

Background

Aim

Materials and methods

Results

Conclusion

Publications

Integrated analysis of exosomal lncRNA and mRNA expression profiles reveals the involvement of lnc-MKRN2-42:1 in the pathogenesis of Parkinson's disease.

Similar Datasets

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