The value of moderate dose escalation for re-irradiation of recurrent or second primary head-and-neck cancer.

ABSTRACT:

Background

Treatment for local and locoregional recurrence or second head-and-neck (H&N) cancers after previous radiotherapy is challenging, and re-irradiation carries a significantly increased risk for radiotherapy-related normal tissue toxicities and treatment failure due to a radioresistant tumor phenotype. Here, we analyzed re-irradiation management and outcomes in patients with recurrent or second primary H&N carcinoma using state-of-the-art diagnostic procedures and radiotherapy techniques.

Methods

Between 2010 and 2019, 48 patients with recurrent or second primary H&N carcinoma received re-radiotherapy at the University of Freiburg Medical Center and were included in this study. Overall survival (OS) and progression-free survival (PFS) were calculated with the Kaplan-

SUBMITTER: Ruhle A 

PROVIDER: S-EPMC7164259 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature