Unknown

Dataset Information

0

Structure of the RNA-dependent RNA polymerase from COVID-19 virus.


ABSTRACT: A novel coronavirus [severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2)] outbreak has caused a global coronavirus disease 2019 (COVID-19) pandemic, resulting in tens of thousands of infections and thousands of deaths worldwide. The RNA-dependent RNA polymerase [(RdRp), also named nsp12] is the central component of coronaviral replication and transcription machinery, and it appears to be a primary target for the antiviral drug remdesivir. We report the cryo-electron microscopy structure of COVID-19 virus full-length nsp12 in complex with cofactors nsp7 and nsp8 at 2.9-angstrom resolution. In addition to the conserved architecture of the polymerase core of the viral polymerase family, nsp12 possesses a newly identified ?-hairpin domain at its N terminus. A comparative analysis model shows how remdesivir binds to this polymerase. The structure provides a basis for the design of new antiviral therapeutics that target viral RdRp.

SUBMITTER: Gao Y 

PROVIDER: S-EPMC7164392 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

altmetric image

Publications


A novel coronavirus [severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2)] outbreak has caused a global coronavirus disease 2019 (COVID-19) pandemic, resulting in tens of thousands of infections and thousands of deaths worldwide. The RNA-dependent RNA polymerase [(RdRp), also named nsp12] is the central component of coronaviral replication and transcription machinery, and it appears to be a primary target for the antiviral drug remdesivir. We report the cryo-electron microscopy structure  ...[more]

Similar Datasets

| S-EPMC7473028 | biostudies-literature
| S-EPMC5378953 | biostudies-literature
| S-EPMC8826900 | biostudies-literature
| S-EPMC8641408 | biostudies-literature
| S-EPMC7684788 | biostudies-literature
| S-EPMC4783868 | biostudies-literature
| S-EPMC23895 | biostudies-literature
| S-EPMC7938656 | biostudies-literature
| S-EPMC7256352 | biostudies-literature
| S-EPMC7461281 | biostudies-literature