Ontology highlight
ABSTRACT:
SUBMITTER: Gao Y
PROVIDER: S-EPMC7164392 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Gao Yan Y Yan Liming L Huang Yucen Y Liu Fengjiang F Zhao Yao Y Cao Lin L Wang Tao T Sun Qianqian Q Ming Zhenhua Z Zhang Lianqi L Ge Ji J Zheng Litao L Zhang Ying Y Wang Haofeng H Zhu Yan Y Zhu Chen C Hu Tianyu T Hua Tian T Zhang Bing B Yang Xiuna X Li Jun J Yang Haitao H Liu Zhijie Z Xu Wenqing W Guddat Luke W LW Wang Quan Q Lou Zhiyong Z Rao Zihe Z
Science (New York, N.Y.) 20200410 6492
A novel coronavirus [severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2)] outbreak has caused a global coronavirus disease 2019 (COVID-19) pandemic, resulting in tens of thousands of infections and thousands of deaths worldwide. The RNA-dependent RNA polymerase [(RdRp), also named nsp12] is the central component of coronaviral replication and transcription machinery, and it appears to be a primary target for the antiviral drug remdesivir. We report the cryo-electron microscopy structure ...[more]