Ontology highlight
ABSTRACT:
SUBMITTER: Stevenson-Jones F
PROVIDER: S-EPMC7165469 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Stevenson-Jones Flint F Woodgate Jason J Castro-Roa Daniel D Zenkin Nikolay N
Proceedings of the National Academy of Sciences of the United States of America 20200401 15
In bacteria, the first two steps of gene expression-transcription and translation-are spatially and temporally coupled. Uncoupling may lead to the arrest of transcription through RNA polymerase backtracking, which interferes with replication forks, leading to DNA double-stranded breaks and genomic instability. How transcription-translation coupling mitigates these conflicts is unknown. Here we show that, unlike replication, translation is not inhibited by arrested transcription elongation comple ...[more]