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The role of EMMPRIN in T cell biology and immunological diseases.

ABSTRACT: EMMPRIN (CD147), originally described as an inducer of the expression of MMPs, has gained attention in its involvement in various immunologic diseases, such that anti-EMMPRIN antibodies are considered as potential therapeutic medications. Given that MMPs are involved in the pathogenesis of various disease states, it is relevant that targeting an upstream inducer would make for an effective therapeutic strategy. Additionally, EMMPRIN is now appreciated to have multiple roles apart from MMP induction, including in cellular functions, such as migration, adhesion, invasion, energy metabolism, as well as T cell activation and proliferation. Here, we review what is known about EMMPRIN in numerous immunologic/inflammatory disease conditions with a particular focus on its complex roles in T cell biology.

SUBMITTER: Hahn JN

PROVIDER: S-EPMC7166407 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature

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The role of EMMPRIN in T cell biology and immunological diseases.

Hahn Jennifer Nancy JN Kaushik Deepak Kumar DK Yong V Wee VW

Journal of leukocyte biology 20150514 1

EMMPRIN (CD147), originally described as an inducer of the expression of MMPs, has gained attention in its involvement in various immunologic diseases, such that anti-EMMPRIN antibodies are considered as potential therapeutic medications. Given that MMPs are involved in the pathogenesis of various disease states, it is relevant that targeting an upstream inducer would make for an effective therapeutic strategy. Additionally, EMMPRIN is now appreciated to have multiple roles apart from MMP induct ...[more]

PMID: 25977287

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