Roles of TroA and TroR in Metalloregulated Growth and Gene Expression in Treponema denticola.

ABSTRACT: The availability of divalent metal cations required as cofactors for microbial metabolism is severely limited in the host environment. Bacteria have evolved highly regulated uptake systems to maintain essential metal homeostasis to meet cellular demands while preventing toxicity. The Tro operon (troABCDR), present in all sequenced Treponema spp., is a member of a highly conserved family of ATP-binding cassette transporters involved in metal cation uptake whose expression is controlled by TroR, a DtxR-like cation-responsive regulatory protein. Transcription of troA responds to divalent manganese and iron (T. denticola) or manganese and zinc (T. pallidum), and metal-dependent TroR binding to the troA promoter represses troA transcription. We r

SUBMITTER: Saraithong P 

PROVIDER: S-EPMC7167467 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature