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Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome.


ABSTRACT: BACKGROUND:In myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), altered membrane excitability often occurs in exercising muscles demonstrating muscle dysfunction regardless of any psychiatric disorder. Increased oxidative stress is also present in many ME/CFS patients and could affect the membrane excitability of resting muscles. METHODS:Seventy-two patients were examined at rest, during an incremental cycling exercise and during a 10-min post-exercise recovery period. All patients had at least four criteria leading to a diagnosis of ME/CFS. To explore muscle membrane excitability, M-waves were recorded during exercise (rectus femoris (RF) muscle) and at rest (flexor digitorum longus (FDL) muscle). Two plasma markers of oxidative stress (thiobarbituric acid reactive substance (TBARS) and oxidation-reduction potential (ORP)) were measured. Plasma potassium (K+) concentration was also measured at rest and at the end of exercise to explore K+ outflow. RESULTS:Thirty-nine patients had marked M-wave alterations in both the RF and FDL muscles during and after exercise while the resting values of plasma TBARS and ORP were increased and exercise-induced K+ outflow was decreased. In contrast, 33 other patients with a diagnosis of ME/CFS had no M-wave alterations and had lower baseline levels of TBARS and ORP. M-wave changes were inversely proportional to TBARS and ORP levels. CONCLUSIONS:Resting muscles of ME/CFS patients have altered muscle membrane excitability. However, our data reveal heterogeneity in some major biomarkers in ME/CFS patients. Measurement of ORP may help to improve the diagnosis of ME/CFS. Trial registration Ethics Committee "Ouest II" of Angers (May 17, 2019) RCB ID: number 2019-A00611-56.

SUBMITTER: Jammes Y 

PROVIDER: S-EPMC7168976 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Altered muscle membrane potential and redox status differentiates two subgroups of patients with chronic fatigue syndrome.

Jammes Yves Y   Adjriou Nabil N   Kipson Nathalie N   Criado Christine C   Charpin Caroline C   Rebaudet Stanislas S   Stavris Chloé C   Guieu Régis R   Fenouillet Emmanuel E   Retornaz Frédérique F  

Journal of translational medicine 20200419 1


<h4>Background</h4>In myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), altered membrane excitability often occurs in exercising muscles demonstrating muscle dysfunction regardless of any psychiatric disorder. Increased oxidative stress is also present in many ME/CFS patients and could affect the membrane excitability of resting muscles.<h4>Methods</h4>Seventy-two patients were examined at rest, during an incremental cycling exercise and during a 10-min post-exercise recovery period.  ...[more]

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