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Functional adrenal insufficiency among tuberculosis-human immunodeficiency virus co-infected patients: a cross-sectional study in Uganda.


ABSTRACT: OBJECTIVE:Tuberculosis (TB) is the leading cause of adrenal insufficiency in resource-limited settings. The adrenal gland is the most commonly affected endocrine organ in TB infection. We assessed factors associated with functional adrenal insufficiency (FAI) among TB-HIV patients with and without drug-resistance in Uganda. Patients with drug-sensitive and drug-resistant TB were enrolled and examined for clinical signs and symptoms of FAI with an early morning serum cortisol level obtained. FAI was defined as early morning serum cortisol??1 month (aOR 2.86; 95% CI 1.4-5.5; p?=?0.002) and abdominal pain (aOR 2.06; 95% CI 1.04-4.09; p?=?0.038) were significantly associated with FAI. Early morning serum cortisol levels should be quantified in TB-HIV co-infected patients with drug-resistant TB.

SUBMITTER: Naggirinya AB 

PROVIDER: S-EPMC7169013 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Functional adrenal insufficiency among tuberculosis-human immunodeficiency virus co-infected patients: a cross-sectional study in Uganda.

Naggirinya Agnes Bwanika AB   Mujugira Andrew A   Meya David B DB   Biraro Irene Andia IA   Mupere Ezekiel E   Worodria William W   Manabe Yukari C YC  

BMC research notes 20200419 1


<h4>Objective</h4>Tuberculosis (TB) is the leading cause of adrenal insufficiency in resource-limited settings. The adrenal gland is the most commonly affected endocrine organ in TB infection. We assessed factors associated with functional adrenal insufficiency (FAI) among TB-HIV patients with and without drug-resistance in Uganda. Patients with drug-sensitive and drug-resistant TB were enrolled and examined for clinical signs and symptoms of FAI with an early morning serum cortisol level obtain  ...[more]

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