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Radiolabelled Peptides for Positron Emission Tomography and Endoradiotherapy in Oncology.


ABSTRACT: This review deals with the development of peptide-based radiopharmaceuticals for the use with positron emission tomography and peptide receptor radiotherapy. It discusses the pros and cons of this class of radiopharmaceuticals as well as the different labelling strategies, and summarises approaches to optimise metabolic stability. Additionally, it presents different target structures and addresses corresponding tracers, which are already used in clinical routine or are being investigated in clinical trials.

SUBMITTER: Rangger C 

PROVIDER: S-EPMC7169460 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Radiolabelled Peptides for Positron Emission Tomography and Endoradiotherapy in Oncology.

Rangger Christine C   Haubner Roland R  

Pharmaceuticals (Basel, Switzerland) 20200130 2


This review deals with the development of peptide-based radiopharmaceuticals for the use with positron emission tomography and peptide receptor radiotherapy. It discusses the pros and cons of this class of radiopharmaceuticals as well as the different labelling strategies, and summarises approaches to optimise metabolic stability. Additionally, it presents different target structures and addresses corresponding tracers, which are already used in clinical routine or are being investigated in clin  ...[more]

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