A reference map of the human binary protein interactome.
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ABSTRACT:
SUBMITTER: Luck K
PROVIDER: S-EPMC7169983 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
A reference map of the human binary protein interactome.
Luck Katja K Kim Dae-Kyum DK Lambourne Luke L Spirohn Kerstin K Begg Bridget E BE Bian Wenting W Brignall Ruth R Cafarelli Tiziana T Campos-Laborie Francisco J FJ Charloteaux Benoit B Choi Dongsic D Coté Atina G AG Daley Meaghan M Deimling Steven S Desbuleux Alice A Dricot Amélie A Gebbia Marinella M Hardy Madeleine F MF Kishore Nishka N Knapp Jennifer J JJ Kovács István A IA Lemmens Irma I Mee Miles W MW Mellor Joseph C JC Pollis Carl C Pons Carles C Richardson Aaron D AD Schlabach Sadie S Teeking Bridget B Yadav Anupama A Babor Mariana M Balcha Dawit D Basha Omer O Bowman-Colin Christian C Chin Suet-Feung SF Choi Soon Gang SG Colabella Claudia C Coppin Georges G D'Amata Cassandra C De Ridder David D De Rouck Steffi S Duran-Frigola Miquel M Ennajdaoui Hanane H Goebels Florian F Goehring Liana L Gopal Anjali A Haddad Ghazal G Hatchi Elodie E Helmy Mohamed M Jacob Yves Y Kassa Yoseph Y Landini Serena S Li Roujia R van Lieshout Natascha N MacWilliams Andrew A Markey Dylan D Paulson Joseph N JN Rangarajan Sudharshan S Rasla John J Rayhan Ashyad A Rolland Thomas T San-Miguel Adriana A Shen Yun Y Sheykhkarimli Dayag D Sheynkman Gloria M GM Simonovsky Eyal E Taşan Murat M Tejeda Alexander A Tropepe Vincent V Twizere Jean-Claude JC Wang Yang Y Weatheritt Robert J RJ Weile Jochen J Xia Yu Y Yang Xinping X Yeger-Lotem Esti E Zhong Quan Q Aloy Patrick P Bader Gary D GD De Las Rivas Javier J Gaudet Suzanne S Hao Tong T Rak Janusz J Tavernier Jan J Hill David E DE Vidal Marc M Roth Frederick P FP Calderwood Michael A MA
Nature 20200408 7803
Global insights into cellular organization and genome function require comprehensive understanding of the interactome networks that mediate genotype-phenotype relationships<sup>1,2</sup>. Here we present a human 'all-by-all' reference interactome map of human binary protein interactions, or 'HuRI'. With approximately 53,000 protein-protein interactions, HuRI has approximately four times as many such interactions as there are high-quality curated interactions from small-scale studies. The integra ...[more]
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