Ontology highlight
ABSTRACT:
SUBMITTER: Ramstead AG
PROVIDER: S-EPMC7170217 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Cell reports 20200301 9
Metabolic pathways regulate T cell development and function, but many remain understudied. Recently, the mitochondrial pyruvate carrier (MPC) was identified as the transporter that mediates pyruvate entry into mitochondria, promoting pyruvate oxidation. Here we find that deleting Mpc1, an obligate MPC subunit, in the hematopoietic system results in a specific reduction in peripheral αβ T cell numbers. MPC1-deficient T cells have defective thymic development at the β-selection, intermediate singl ...[more]