Hepatic Lipid Catabolism via PPAR?-Lysosomal Crosstalk.

ABSTRACT: Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors which belong to the nuclear hormone receptor superfamily. They regulate key aspects of energy metabolism within cells. Recently, PPAR? has been implicated in the regulation of autophagy-lysosomal function, which plays a key role in cellular energy metabolism. PPAR? transcriptionally upregulates several genes involved in the autophagy-lysosomal degradative pathway that participates in lipolysis of triglycerides within the hepatocytes. Interestingly, a reciprocal regulation of PPAR? nuclear action by autophagy-lysosomal activity also exists with implications in lipid metabolism. This review succinctly discusses the unique relationship between PPAR? nuclear action and lysosomal activity and explores its impact on hepatic lipid homeostasis under pathological conditions such as non-alcoholic fatty liver disease (NAFLD).

SUBMITTER: Sinha RA 

PROVIDER: S-EPMC7170715 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature