Ontology highlight
ABSTRACT:
SUBMITTER: Van Wyngene L
PROVIDER: S-EPMC7005534 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
EMBO molecular medicine 20200109 2
Despite intensive research and constant medical progress, sepsis remains one of the most urgent unmet medical needs of today. Most studies have been focused on the inflammatory component of the disease; however, recent advances support the notion that sepsis is accompanied by extensive metabolic perturbations. During times of limited caloric intake and high energy needs, the liver acts as the central metabolic hub in which PPARα is crucial to coordinate the breakdown of fatty acids. The role of ...[more]