Ontology highlight
ABSTRACT:
SUBMITTER: Jacques LC
PROVIDER: S-EPMC7170840 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Jacques Laura C LC Panagiotou Stavros S Baltazar Murielle M Senghore Madikay M Khandaker Shadia S Xu Rong R Bricio-Moreno Laura L Yang Marie M Dowson Christopher G CG Everett Dean B DB Neill Daniel R DR Kadioglu Aras A
Nature communications 20200420 1
Streptococcus pneumoniae serotype 1 is the predominant cause of invasive pneumococcal disease in sub-Saharan Africa, but the mechanism behind its increased invasiveness is not well understood. Here, we use mouse models of lung infection to identify virulence factors associated with severe bacteraemic pneumonia during serotype-1 (ST217) infection. We use BALB/c mice, which are highly resistant to pneumococcal pneumonia when infected with other serotypes. However, we observe 100% mortality and hig ...[more]