Ontology highlight
ABSTRACT:
SUBMITTER: Chen J
PROVIDER: S-EPMC7171161 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Chen Jianwen J He Ruirui R Sun Wanwei W Gao Ru R Peng Qianwen Q Zhu Liwen L Du Yanyun Y Ma Xiaojian X Guo Xiaoli X Zhang Huazhi H Tan Chengcheng C Wang Junhan J Zhang Wei W Weng Xiufang X Man Jianghong J Bauer Hermann H Wang Qing K QK Martin Bradley N BN Zhang Cun-Jin CJ Li Xiaoxia X Wang Chenhui C
Nature communications 20200420 1
The TAGAP gene locus has been linked to several infectious diseases or autoimmune diseases, including candidemia and multiple sclerosis. While previous studies have described a role of TAGAP in T cells, much less is known about its function in other cell types. Here we report that TAGAP is required for Dectin-induced anti-fungal signaling and proinflammatory cytokine production in myeloid cells. Following stimulation with Dectin ligands, TAGAP is phosphorylated by EPHB2 at tyrosine 310, which br ...[more]