Ontology highlight
ABSTRACT:
SUBMITTER: Goodridge HS
PROVIDER: S-EPMC3084546 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Goodridge Helen S HS Reyes Christopher N CN Becker Courtney A CA Katsumoto Tamiko R TR Ma Jun J Wolf Andrea J AJ Bose Nandita N Chan Anissa S H AS Magee Andrew S AS Danielson Michael E ME Weiss Arthur A Vasilakos John P JP Underhill David M DM
Nature 20110401 7344
Innate immune cells must be able to distinguish between direct binding to microbes and detection of components shed from the surface of microbes located at a distance. Dectin-1 (also known as CLEC7A) is a pattern-recognition receptor expressed by myeloid phagocytes (macrophages, dendritic cells and neutrophils) that detects β-glucans in fungal cell walls and triggers direct cellular antimicrobial activity, including phagocytosis and production of reactive oxygen species (ROS). In contrast to inf ...[more]