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General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases.

ABSTRACT: Modular polyketide synthases (PKSs) are enzymatic assembly lines that fuse carbon fragments into complex chiral products. Here, their synthetic logic is employed to chemoenzymatically generate two-stereocenter triketides. Each of the four stereoisomers was constructed in a stereocontrolled manner using C-acylation and two PKS ketoreductases possessing opposite stereoselectivities.

SUBMITTER: Zhang Z

PROVIDER: S-EPMC7172026 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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General chemoenzymatic route to two-stereocenter triketides employing assembly line ketoreductases.

Zhang Zhicheng Z Cepeda Alexis J AJ Robles Mireya L ML Hirsch Melissa M Kumru Kaan K Zhou Jina A JA Keatinge-Clay Adrian T AT

Chemical communications (Cambridge, England) 20191201 1

Modular polyketide synthases (PKSs) are enzymatic assembly lines that fuse carbon fragments into complex chiral products. Here, their synthetic logic is employed to chemoenzymatically generate two-stereocenter triketides. Each of the four stereoisomers was constructed in a stereocontrolled manner using C-acylation and two PKS ketoreductases possessing opposite stereoselectivities. ...[more]

PMID: 31799975

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