Ontology highlight
ABSTRACT:
SUBMITTER: Meng C
PROVIDER: S-EPMC6176721 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Meng Caicai C Sasmal Aniruddha A Zhang Yan Y Gao Tian T Liu Chang-Cheng CC Khan Naazneen N Varki Ajit A Wang Fengshan F Cao Hongzhi H
Angewandte Chemie (International ed. in English) 20180625 29
O-Mannose glycans account up to 30 % of total O-glycans in the brain. Previous synthesis and functional studies have only focused on the core M3 O-mannose glycans of α-dystroglycan, which are a causative factor for various muscular diseases. In this study, a highly efficient chemoenzymatic strategy was developed that enabled the first collective synthesis of 63 core M1 and core M2 O-mannose glycans. This chemoenzymatic strategy features the gram-scale chemical synthesis of five judiciously desig ...[more]