Ontology highlight
ABSTRACT:
SUBMITTER: Sakai T
PROVIDER: S-EPMC5366856 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Sakai Tatsuya T Nishimura Shin I SI Naito Tadasuke T Saito Mineki M
Scientific reports 20170327
Influenza A virus (IAV) membrane proteins hemagglutinin (HA) and neuraminidase (NA) are determinants of virus infectivity, transmissibility, pathogenicity, host specificity, and major antigenicity. HA binds to a virus receptor, a sialoglycoprotein or sialoglycolipid, on the host cell and mediates virus attachment to the cell surface. The hydrolytic enzyme NA cleaves sialic acid from viral receptors and accelerates the release of progeny virus from host cells. In this study, we identified a novel ...[more]