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Metabolomics of childhood exposure to perfluoroalkyl substances: a cross-sectional study.


ABSTRACT: INTRODUCTION:Exposure to perfluoroalkyl substances (PFAS), synthetic and persistent chemicals used in commercial and industrial processes, are associated with cardiometabolic dysfunction and related risk factors including reduced birth weight, excess adiposity, and dyslipidemia. Identifying the metabolic changes induced by PFAS exposure could enhance our understanding of biological pathways underlying PFAS toxicity. OBJECTIVE:To identify metabolic alterations associated with serum concentrations of four PFAS in children using a metabolome-wide association study. METHODS:We performed untargeted metabolomic profiling by liquid chromatography with ultra-high-resolution mass spectrometry, and separately quantified serum concentrations of perfluorooctanoic acid, perfluorooctanesulfonic acid, perfluorononanoic acid, and perfluorohexanesulfonic acid (PFHxS) for 114 8-year old children from Cincinnati, OH. We evaluated associations between each serum PFAS concentration and 16,097 metabolic features using linear regression adjusted for child age, sex, and race with a false discovery rate?

SUBMITTER: Kingsley SL 

PROVIDER: S-EPMC7172933 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Metabolomics of childhood exposure to perfluoroalkyl substances: a cross-sectional study.

Kingsley Samantha L SL   Walker Douglas I DI   Calafat Antonia M AM   Chen Aimin A   Papandonatos George D GD   Xu Yingying Y   Jones Dean P DP   Lanphear Bruce P BP   Pennell Kurt D KD   Braun Joseph M JM  

Metabolomics : Official journal of the Metabolomic Society 20190621 7


<h4>Introduction</h4>Exposure to perfluoroalkyl substances (PFAS), synthetic and persistent chemicals used in commercial and industrial processes, are associated with cardiometabolic dysfunction and related risk factors including reduced birth weight, excess adiposity, and dyslipidemia. Identifying the metabolic changes induced by PFAS exposure could enhance our understanding of biological pathways underlying PFAS toxicity.<h4>Objective</h4>To identify metabolic alterations associated with serum  ...[more]

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