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Frugal filtering optical lenses for point-of-care diagnostics.


ABSTRACT: Infectious diseases are the leading cause of morbidity and mortality in low and middle income countries (LMICs). Rapid diagnosis of infections in LMICs presents many challenges, especially in rural areas where access to health care, including diagnostics, is poor. Microscopy is one of the most commonly used platforms to diagnose bacterial infections on clinical samples. Fluorescence microscopy has high sensitivity and specificity but to date is mostly performed within a laboratory setting due to the high-cost, low portability and highly specialist nature of equipment. Point-of-care diagnostics could offer a solution to the challenge of infection diagnosis in LMICs. In this paper we present frugal, easy to manufacture, doped polydimethylsiloxane filtering optical lenses that can be integrated into smartphone microscopes for immediate detection of fluorescently labelled bacteria. This provides a breakthrough technology platform for point-of-care diagnostics.

SUBMITTER: Long J 

PROVIDER: S-EPMC7173883 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Frugal filtering optical lenses for point-of-care diagnostics.

Long Joanna J   Parker Helen E HE   Ehrlich Katjana K   Tanner Michael G MG   Dhaliwal Kevin K   Mills Bethany B  

Biomedical optics express 20200309 4


Infectious diseases are the leading cause of morbidity and mortality in low and middle income countries (LMICs). Rapid diagnosis of infections in LMICs presents many challenges, especially in rural areas where access to health care, including diagnostics, is poor. Microscopy is one of the most commonly used platforms to diagnose bacterial infections on clinical samples. Fluorescence microscopy has high sensitivity and specificity but to date is mostly performed within a laboratory setting due to  ...[more]

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