Pitfalls in quantitative myocardial PET perfusion I: Myocardial partial volume correction.

ABSTRACT:

Background

PET quantitative myocardial perfusion requires correction for partial volume loss due to one-dimensional LV wall thickness smaller than scanner resolution.

Methods

We aimed to assess accuracy of risk stratification for death, MI, or revascularization after PET using partial volume corrections derived from two-dimensional ACR and three-dimensional NEMA phantoms for 3987 diagnostic rest-stress perfusion PETs and 187 MACE events. NEMA, ACR, and Tree phantoms were imaged with Rb-82 or F-18 for size-dependent partial volume loss. Perfusion and Coronary Flow Capacity were recalculated using different ACR- and NEMA-derived partial volume corrections compared by Kolmogorov-Smirnov statistics to standard perfusion metrics with established correlations with MACE.

Results

SUBMITTER: Lance Gould K 

PROVIDER: S-EPMC7174249 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature