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Urinary and serum oxysterols in children: developmental pattern and potential biomarker for pediatric liver disease.

ABSTRACT: Few reports describe oxysterols in healthy children or in children with liver disease. We aimed to determine whether developmental changes in urinary and serum oxysterols occur during childhood, and to assess whether oxysterols might be biomarkers for pediatric liver disease. Healthy children enrolled as subjects (36 and 35 for urine and serum analysis, respectively) included neonates, infants, preschoolers, and school-age children, studied along with 14 healthy adults and 8 children with liver disease. We quantitated 7 oxysterols including 4?-, 20(S)-, 22(S)-, 22(R)-, 24(S)-, 25-, and 27-hydroxycholesterol using liquid chromatography/electrospray ionization-tandem mass spectrometry. Urinary total oxysterols were significantly greater in neonates than in infants (P?

SUBMITTER: Takaki Y

PROVIDER: S-EPMC7174363 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Urinary and serum oxysterols in children: developmental pattern and potential biomarker for pediatric liver disease.

Takaki Yugo Y Mizuochi Tatsuki T Takei Hajime H Eda Keisuke K Konishi Ken-Ichiro KI Ishihara Jun J Kinoshita Masahiro M Hashizume Naoki N Yamashita Yushiro Y Nittono Hiroshi H Kimura Akihiko A

Scientific reports 20200421 1

Few reports describe oxysterols in healthy children or in children with liver disease. We aimed to determine whether developmental changes in urinary and serum oxysterols occur during childhood, and to assess whether oxysterols might be biomarkers for pediatric liver disease. Healthy children enrolled as subjects (36 and 35 for urine and serum analysis, respectively) included neonates, infants, preschoolers, and school-age children, studied along with 14 healthy adults and 8 children with liver ...[more]

PMID: 32317688

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Dataset Information

Urinary and serum oxysterols in children: developmental pattern and potential biomarker for pediatric liver disease.

Publications

Urinary and serum oxysterols in children: developmental pattern and potential biomarker for pediatric liver disease.

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