Ontology highlight
ABSTRACT:
SUBMITTER: Alonso-Alonso R
PROVIDER: S-EPMC7174413 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Alonso-Alonso Ruth R Mondéjar Rufino R Martínez Nerea N García-Diaz Nuria N Pérez Cristina C Merino David D Rodríguez Marta M Esteve-Codina Anna A Fuste Berta B Gut Marta M Burrows Francis F Scholz Catherine C Vaqué Jose Pedro JP Gualberto Antonio A Piris Miguel Ángel MÁ
Scientific reports 20200421 1
Patients diagnosed with T-cell leukemias and T-cell lymphomas (TCLs) still have a poor prognosis and an inadequate response to current therapies, highlighting the need for targeted treatments. We have analyzed the potential therapeutic value of the farnesyltransferase inhibitor, tipifarnib, in 25 TCL cell lines through the identification of genomic and/or immunohistochemical markers of tipifarnib sensitivity. More than half of the cell lines (60%) were considered to be sensitive. Tipifarnib redu ...[more]