Genome-wide association studies and Mendelian randomization analyses for leisure sedentary behaviours.
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ABSTRACT:
SUBMITTER: van de Vegte YJ
PROVIDER: S-EPMC7174427 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Genome-wide association studies and Mendelian randomization analyses for leisure sedentary behaviours.
van de Vegte Yordi J YJ Said M Abdullah MA Rienstra Michiel M van der Harst Pim P Verweij Niek N
Nature communications 20200421 1
Leisure sedentary behaviours are associated with increased risk of cardiovascular disease, but whether this relationship is causal is unknown. The aim of this study is to identify genetic determinants associated with leisure sedentary behaviours and to estimate the potential causal effect on coronary artery disease (CAD). Genome wide association analyses of leisure television watching, leisure computer use and driving behaviour in the UK Biobank identify 145, 36 and 4 genetic loci (P < 1×10<sup> ...[more]
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