Dataset Information

Association of sedentary and physical activity behaviours with body composition: a genome-wide association and Mendelian randomisation study.

ABSTRACT:

Objectives

Studies suggest that body composition can be independently improved through physical activity (PA). We performed a Mendelian randomisation (MR) study to test the incremental benefits of sedentary behaviour and various PA exposures on body composition outcomes as assessed by anthropometric indices, lean body mass (kg), body fat (%) and visceral adipose tissue (VAT) (kg).

Methods

Genetic instruments were identified for both self-reported and accelerometer-measured sedentary behaviour and PA. Outcomes included anthropometric and dual-energy X-ray absorptiometry measures of adiposity, extracted from the UK Biobank and the largest available consortia. Multivariable MR (MVMR) included educational attainment as a covariate to address potential confounding. Sensitivity analyses were evaluated for weak instrument bias and pleiotropic effects.

Results

We did not identify consistent associations between genetically predicted self-reported and accelerometer-measured sedentary behaviour and body composition outcomes. All analyses for self-reported moderate PA were null for body composition outcomes. Genetically predicted PA at higher intensities was protective against VAT in MR and MVMR analyses of both accelerometer-measured vigorous PA (MVMR β=-0.15, 95% CI: -0.24 to -0.07, p<0.001) and self-reported participation in strenuous sports or other exercises (MVMR β=-0.27, 95% CI: -0.52 to -0.01, p=0.034) was robust across several sensitivity analyses.

Conclusions

We did not identify evidence of a causal relationship between genetically predicted PA and body composition, with the exception of a putatively protective effect of higher-intensity PA on VAT. Protective effects of PA against VAT may support prior evidence of biological pathways through which PA decreases risk of downstream cardiometabolic diseases.

SUBMITTER: Ramadan FA

PROVIDER: S-EPMC9351346 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Publications

Association of sedentary and physical activity behaviours with body composition: a genome-wide association and Mendelian randomisation study.

Ramadan Ferris A FA Bea Jennifer W JW Garcia David O DO Ellingson Katherine D KD Canales Robert A RA Raichlen David A DA Klimentidis Yann C YC

BMJ open sport & exercise medicine 20220802 3

<h4>Objectives</h4>Studies suggest that body composition can be independently improved through physical activity (PA). We performed a Mendelian randomisation (MR) study to test the incremental benefits of sedentary behaviour and various PA exposures on body composition outcomes as assessed by anthropometric indices, lean body mass (kg), body fat (<i>%</i>) and visceral adipose tissue (VAT) (kg).<h4>Methods</h4>Genetic instruments were identified for both self-reported and accelerometer-measured ...[more]

PMID: 35990758

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Dataset Information

Association of sedentary and physical activity behaviours with body composition: a genome-wide association and Mendelian randomisation study.

Objectives

Methods

Results

Conclusions

Publications

Association of sedentary and physical activity behaviours with body composition: a genome-wide association and Mendelian randomisation study.

Similar Datasets

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