Unknown

Dataset Information

0

The Role of ERRFI1+808T/G Polymorphism in Diabetic Nephropathy.


ABSTRACT: Nephropathy is a common diabetes complication. ERRFI1 gene which participates in various cellular pathways has been proposed as a candidate gene in diabetic nephropathy. This study aimed to investigate the role of +808T/G polymorphism (rs377349) in ERRFI1 gene in diabetic nephropathy. In this case-control study, patients including diabetes with nephropathy (DN=104), type 2 diabetes without nephropathy (DM=100), and healthy controls (HC=106) were included. DNA was extracted from blood, and genotyping of the +808T/G polymorphism was carried out using PCR-RFLP technique. The differences for genotype and allele frequencies for +808T/G polymorphism in ERRFI1 gene between DN vs. HC and DN+DM vs. HC were significant (P<0.05) while no significant difference between DN and DM was observed. The allele frequencies were significantly different in DN vs. HC and DN+DM vs. HC in males but not in females. G allele of +808T/G polymorphism in ERRFI1 gene has no significant role in development and progression of diabetic nephropathy in diabetes patients while it is a risk allele for developing diabetes in Iranian population.

SUBMITTER: Asgarbeik S 

PROVIDER: S-EPMC7175607 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

altmetric image

Publications

The Role of ERRFI1+808T/G Polymorphism in Diabetic Nephropathy.

Asgarbeik Saeedeh S   Mohammad Amoli Mahsa M   Enayati Samaneh S   Bandarian Fatemeh F   Nasli-Esfahani Ensieh E   Forouzanfar Katayoon K   Razi Farideh F   Angaji Seyed Abdolhamid SA  

International journal of molecular and cellular medicine 20190615 Suppl1


Nephropathy is a common diabetes complication. <i>ERRFI1</i> gene which participates in various cellular pathways has been proposed as a candidate gene in diabetic nephropathy. This study aimed to investigate the role of +808T/G polymorphism (rs377349) in <i>ERRFI1</i> gene in diabetic nephropathy. In this case-control study, patients including diabetes with nephropathy (DN=104), type 2 diabetes without nephropathy (DM=100), and healthy controls (HC=106) were included. DNA was extracted from blo  ...[more]

Similar Datasets

| S-EPMC4402911 | biostudies-literature
| S-EPMC6394539 | biostudies-literature
| S-EPMC9865841 | biostudies-literature
| S-EPMC5832179 | biostudies-literature
2004-04-01 | GSE1009 | GEO
| S-EPMC4073425 | biostudies-literature
2016-08-01 | E-GEOD-84908 | biostudies-arrayexpress
| S-EPMC6333004 | biostudies-literature
| S-EPMC5070958 | biostudies-literature
2016-08-01 | GSE84908 | GEO