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Diabetic nephropathy

ABSTRACT: Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy Keywords = Diabetes Keywords = kidney Keywords = glomeruli Keywords: other

ORGANISM(S): Homo sapiens

PROVIDER: GSE1009 | GEO | 2004/04/01

SECONDARY ACCESSION(S): PRJNA87073

REPOSITORIES: GEO

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Gene expression profiling in glomeruli from human kidneys with diabetic nephropathy

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Project description:We investigated the gene expression profiles of RNA isolated from kidney glomeruli from aged, 25 week old type-2 diabetic (db/db) and non-diabetic mice. In order to investigate the consequences of hyperglycemia on the pathogenesis and progression of diabetic nephropathy Kidney glomeruli from 3 diabetic and 3 non-diabetic, control mice were isolated and RNA purified for RNA-Seq analysis on the Illumina HiSeq 2000. The goal of the project was to generate comprehensive list of noncoding RNA genes differentially regulated between the two conditions in order to identify novel targets for further study.

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