Ontology highlight
ABSTRACT:
SUBMITTER: Matsumoto Y
PROVIDER: S-EPMC7175968 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Matsumoto Yasuyuki Y Kudelka Matthew R MR Hanes Melinda S MS Lehoux Sylvain S Dutta Sucharita S Jones Mark B MB Stackhouse Kathryn A KA Cervoni Gabrielle E GE Heimburg-Molinaro Jamie J Smith David F DF Ju Tongzhong T Chaikof Elliot L EL Cummings Richard D RD
Glycobiology 20200401 5
The Tn antigen is a neoantigen abnormally expressed in many human carcinomas and expression correlates with metastasis and poor survival. To explore its biomarker potential, new antibodies are needed that specifically recognize this antigen in tumors. Here we generated two recombinant antibodies to the Tn antigen, Remab6 as a chimeric human IgG1 antibody and ReBaGs6 as a murine IgM antibody and characterized their specificities using multiple biochemical and biological approaches. Both Remab6 an ...[more]