Ontology highlight
ABSTRACT:
SUBMITTER: Tobias F
PROVIDER: S-EPMC7176368 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Tobias Fernando F McIntosh Julie C JC LaBonia Gabriel J GJ Boyce Matthew W MW Lockett Matthew R MR Hummon Amanda B AB
Analytical chemistry 20191206 24
Many potential chemotherapeutics fail to reach patients. One of the key reasons is that compounds are tested during the drug discovery stage in two-dimensional (2D) cell cultures, which are often unable to accurately model in vivo outcomes. Three-dimensional (3D) in vitro tumor models are more predictive of chemotherapeutic effectiveness than 2D cultures, and thus, their implementation during the drug screening stage has the potential to more accurately evaluate compounds earlier, saving both ti ...[more]