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A New Antimalarial Noreudesmane Sesquiterpenoid from Dobinea delavayi.


ABSTRACT: One previously undescribed angeloylated noreudesmane sesquiterpenoid, dobinin O (1), along with four known eudesmane sesquiterpenoids (2-5) were isolated from the peeled roots of Dobinea delavayi. Their structures were elucidated by extensive spectroscopic data analyses. In addition, compound 1 exhibited moderate antimalarial activity against Plasmodium yoelii BY265RFP with the inhibition ratio of 17.8?±?13.3% at the dose of 30 mg/kg/day.

SUBMITTER: Wu XR 

PROVIDER: S-EPMC7176782 | biostudies-literature |

REPOSITORIES: biostudies-literature

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