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Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood.

ABSTRACT: Three new sesquiterpenoids (1-3) and one new sesquiterpenoid derivative (4), along with three known sesquiterpenoids (5-7), were isolated from the 95% ethanolic extract of Chinese eaglewood [Aquilaria sinensis (Lour.) Gilg]. The structures of these compounds were elucidated through extensive analysis of spectroscopic data including IR, NMR, HRESIMS, and X-ray diffraction experiments. In addition, the above new compounds were detected for their bioactivities against LPS-induced NO production in RAW 264.7 cells. Among them, compound 2 exhibited obvious anti-inflammatory activity with an IC50 value of 8.1 ?M.

SUBMITTER: Zhao H

PROVIDER: S-EPMC6274321 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Three New Sesquiterpenoids and One New Sesquiterpenoid Derivative from Chinese Eaglewood.

Zhao Huan H Peng Qinghua Q Han Zhuzhen Z Yang Li L Wang Zhengtao Z

Molecules (Basel, Switzerland) 20160227 3

Three new sesquiterpenoids (1-3) and one new sesquiterpenoid derivative (4), along with three known sesquiterpenoids (5-7), were isolated from the 95% ethanolic extract of Chinese eaglewood [Aquilaria sinensis (Lour.) Gilg]. The structures of these compounds were elucidated through extensive analysis of spectroscopic data including IR, NMR, HRESIMS, and X-ray diffraction experiments. In addition, the above new compounds were detected for their bioactivities against LPS-induced NO production in R ...[more]

PMID: 26927050

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