Ontology highlight
ABSTRACT:
SUBMITTER: Ding Y
PROVIDER: S-EPMC7177145 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Ding Yu Y Fei Yiyan Y Lu Boxun B
Trends in pharmacological sciences 20200423 7
Traditional drug discovery focuses on identifying direct inhibitors of target proteins. This typically relies on a measurable biochemical readout and accessible binding sites whose occupancy influences the function of the target protein. These requirements preclude many disease-causing proteins from being 'druggable' targets, and these proteins are categorized as 'undruggable'. The proteolysis-targeting chimera (PROTAC) technology provides powerful tools to degrade these undruggable targets and ...[more]