Ontology highlight
ABSTRACT:
SUBMITTER: Aversa I
PROVIDER: S-EPMC7177412 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Aversa Ilenia I Malanga Donatella D Fiume Giuseppe G Palmieri Camillo C
International journal of molecular sciences 20200330 7
The T cells are key players of the response to checkpoint blockade immunotherapy (CBI) and monitoring the strength and specificity of antitumor T-cell reactivity remains a crucial but elusive component of precision immunotherapy. The entire assembly of T-cell receptor (TCR) sequences accounts for antigen specificity and strength of the T-cell immune response. The TCR repertoire hence represents a "footprint" of the conditions faced by T cells that dynamically evolves according to the challenges ...[more]