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Phenylethanol glycosides from the seeds of Aesculus chinensis var. chekiangensis.

ABSTRACT: Three new phenylethanol glycosides (1-3) and one known analogue (4) were isolated from the seeds of Aesculus chinensis Bge. var. chekiangensis. To the best of our knowledge, this represents the first isolation of phenylethanol glycosides from the genus of Aesculus, which enriched its chemical composition. Structure elucidations were performed via extensive NMR and HRESIMS data together with comparison with literature data. Thereafter, the isolated compounds were assayed for their neuroprotective activities against CoCl2-induced cytotoxicity in PC12 cells and compound 3 exhibited moderate activity.

SUBMITTER: Zhang N 

PROVIDER: S-EPMC7178748 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature

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Phenylethanol glycosides from the seeds of <i>Aesculus chinensis</i> var. <i>chekiangensis</i>.

Zhang Nan N   Liu Di D   Wei Shuxiang S   Cao Shijie S   Feng Xinchi X   Wang Kai K   Ding Liqin L   Qiu Feng F  

BMC chemistry 20200422 1

Three new phenylethanol glycosides (<b>1</b>-<b>3</b>) and one known analogue (<b>4</b>) were isolated from the seeds of <i>Aesculus chinensis</i> Bge. var. <i>chekiangensis</i>. To the best of our knowledge, this represents the first isolation of phenylethanol glycosides from the genus of <i>Aesculus</i>, which enriched its chemical composition. Structure elucidations were performed via extensive NMR and HRESIMS data together with comparison with literature data. Thereafter, the isolated compou  ...[more]

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