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Targeted Isolation of Indole Alkaloids from Streptomyces sp. CT37.


ABSTRACT: Four compounds (1-4) were isolated from the extracts of Streptomyces sp. CT37 using bioassay in conjunction with mass spectrometric molecular networking (MN) driven isolation. Their complete structures were established by high-resolution electrospray ionization mass spectrometry (HR-ESIMS), and 1D and 2D nuclear magnetic resonance (NMR) data. Legonimide 1 was identified as a new alkaloid containing a rare linear imide motif in its structure, while compounds 2-4 were already known and their structures were elucidated as 1H-indole-3-carbaldehyde, actinopolymorphol B, (2R,3R)-1-phenylbutane-2,3-diol, respectively. The biosynthetic pathways of 1-4 were proposed based on the reported biogenesis of indole alkaloids in literature. Bioactivity tests for 1 and 2 revealed moderate growth inhibition activity against Candida albicans ATCC 10231 with MIC95 values of 21.54 µg/mL and 11.47 µg/mL, respectively.

SUBMITTER: Fang Q 

PROVIDER: S-EPMC7179168 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Targeted Isolation of Indole Alkaloids from <i>Streptomyces</i> sp. CT37.

Fang Qing Q   Maglangit Fleurdeliz F   Mugat Morgane M   Urwald Caroline C   Kyeremeh Kwaku K   Deng Hai H  

Molecules (Basel, Switzerland) 20200302 5


Four compounds (<b>1</b>-<b>4</b>) were isolated from the extracts of <i>Streptomyces</i> sp. CT37 using bioassay in conjunction with mass spectrometric molecular networking (MN) driven isolation. Their complete structures were established by high-resolution electrospray ionization mass spectrometry (HR-ESIMS), and 1D and 2D nuclear magnetic resonance (NMR) data. Legonimide <b>1</b> was identified as a new alkaloid containing a rare linear imide motif in its structure, while compounds <b>2-4</b>  ...[more]

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