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A Concise Approach to N-Substituted Rhodanines through a Base-Assisted One-Pot Coupling and Cyclization Process.

ABSTRACT: An efficient approach to obtain functionalized rhodanines was developed through a base-assisted one-pot coupling and continuous cyclization of a primary amine, carbon disulfide, and methyl (2-chloroacetyl)carbamate. This conversion tolerates a broad range of functional groups and can be used to scale the preparation of N-substituted rhodanines in excellent yields.

SUBMITTER: Liang Y

PROVIDER: S-EPMC7179173 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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A Concise Approach to <i>N</i>-Substituted Rhodanines through a Base-Assisted One-Pot Coupling and Cyclization Process.

Liang Yongxi Y Tang Mei-Lin ML Huo Zhipeng Z Zhang Chenchen C Sun Xun X

Molecules (Basel, Switzerland) 20200304 5

An efficient approach to obtain functionalized rhodanines was developed through a base-assisted one-pot coupling and continuous cyclization of a primary amine, carbon disulfide, and methyl (2-chloroacetyl)carbamate. This conversion tolerates a broad range of functional groups and can be used to scale the preparation of <i>N</i>-substituted rhodanines in excellent yields. ...[more]

PMID: 32143323

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