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Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles.

ABSTRACT: A one-pot, two-step synthesis of bis-pyrrolidinone tetrazoles has been established via the Ugi-Azide reaction using methyl levulinate, primary amines, isocyanides and azidotrimethylsilane with subsequent acid treatment to catalyze the lactam formation. The efficiency of the protocol was established followed by a successful transition to library production in four 24-well plates.

SUBMITTER: Gunawan S

PROVIDER: S-EPMC3299871 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature

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Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles.

Gunawan Steven S Petit Joachim J Hulme Christopher C

ACS combinatorial science 20120215 3

A one-pot, two-step synthesis of bis-pyrrolidinone tetrazoles has been established via the Ugi-Azide reaction using methyl levulinate, primary amines, isocyanides and azidotrimethylsilane with subsequent acid treatment to catalyze the lactam formation. The efficiency of the protocol was established followed by a successful transition to library production in four 24-well plates. ...[more]

PMID: 22330239

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