Ontology highlight
ABSTRACT:
SUBMITTER: Wu L
PROVIDER: S-EPMC7179225 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20200305 5
A series of benzimidazole-derived chalcones containing aromatic amide substituent were designed and synthesized. All of the chalcone compounds were tested for their in vitro antitumor activity against human cancer cell lines (HCT116, HepG2, A549, and CRL-5908). The antiproliferative activity of compounds <b>3</b>, <b>6</b>, <b>9</b>, <b>14</b>, <b>15</b>, <b>16</b> against HCT116 cells was significantly better than that that of 5-Fluorouracil (IC50: 94.63 µM). The antitumor activity of these com ...[more]