Ontology highlight
ABSTRACT:
SUBMITTER: Romagnoli R
PROVIDER: S-EPMC2714055 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Bioorganic & medicinal chemistry letters 20090212 7
Research into the anti-tumor properties of chalcones has received significant attention over the last few years Two novel large series of alpha-bromoacryloylamido chalcones 1a-m and 2a-k containing a pair of Michael acceptors in their structures, corresponding to the alpha-bromoacryloyl moiety and the alpha,beta-unsaturated ketone system of the chalcone framework, were synthesized and evaluated for antiproliferative activity against five cancer cell lines. Such hybrid derivatives demonstrated si ...[more]